The researchers say their findings highlight the need to treat patients with Mycobacterium abscessus infection immediately counter to current medical practice Peripheral innate immunophenotype in neurodegenerative disease bloodbased profiles and links to survival
DOI 101126scienceabb8699 Corpus ID 233448805 Stepwise pathogenic evolution of Mycobacterium abscessus articleBryant2021StepwisePE titleStepwise pathogenic evolution of Mycobacterium abscessus authorJosephine M Bryant and Karen P Brown and Sophie Burbaud and Isobel Everall and Juan Manuel Belardinelli and Daniela RodriguezRincon and Dorothy M Grogono and Chelsea M Peterson
Stepwise pathogenic evolution of Mycobacterium abscessus
Stepwise pathogenic evolution of Mycobacterium abscessus
Steps involved in mycobacterial pathogenic evolution 1 Horizontal gene acquisition by environmental clones drives saltational evolution and gives rise to the ancestors of the dominant circulating clones of M abscessus and virulent clones within other mycobacterial species 2 Allopatric withinhost adaptation
Stepwise pathogenic evolution of Mycobacterium abscessus Science 101126scienceabb8699
Stepwise pathogenic evolution of Mycobacterium abscessus
Stepwise pathogenic evolution of Mycobacterium abscessus
Stepwise Pathogenic Evolution Of Mycobacterium Abscessus
Stepwise pathogenic evolution of Mycobacterium abscessus
Although almost all mycobacterial species are saprophytic environmental organisms a few such as Mycobacterium tuberculosis have evolved to cause transmissible human infectionBy analyzing the recent emergence and spread of the environmental organism M abscessus through the global cystic fibrosis population we have defined key generalizable steps involved in the pathogenic evolution of
Bryant J M et al Stepwise pathogenic evolution of Mycobacterium abscessus Science 372 eabb8699 2021 Article CAS PubMed PubMed Central Google Scholar
Although almost all mycobacterial species are saprophytic environmental organisms a few such as Mycobacterium tuberculosis have evolved to cause transmissible human infection By analyzing the recent emergence and spread of the environmental organism M abscessus through the global cystic fibrosis population we have defined key generalizable steps involved in the pathogenic evolution of
Stepwise pathogenic evolution of Mycobacterium abscessus
the pathogenic evolution of mycobacteria RATIONALE M abscessus a multidrugresistant s p e c i e so fn o n t u b e r c u l o u sm y c o b a c t e r i a h a s
Stepwise Pathogenic Evolution Of Mycobacterium Abscessus
Stepwise pathogenic evolution of Mycobacterium abscessus
Mycobacteria are mostly environmental saprotrophs but during human history some have become our pathogens In the past 50 years or so intractable and virulent infections of Mycobacterium abscessus have emerged in people with cystic fibrosis Bryant et al investigated how these mycobacteria have evolved into human pathogens so quickly see the Perspective by Brugha and Spencer
Saltational evolution of M abscessus dominant circulating clones A Pangenome graph of M abscessus constructed using Panaroo where nodes represent clusters of orthologous genes and two nodes are connected by an edge if they are adjacent on a contig in any sample from the population defines gene gain events associated with the emergence of DCC1 purple DCC2 blue and DCC3 orange
Microevolution reinfection and highly complex genomic diversity in
PATHOGEN EVOLUTION Stepwise pathogenic evolution of Mycobacterium abscessus
Stepwise pathogenic evolution of Mycobacterium abscessus Science AAAS